Endoplasmic reticulum membrane organization

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRBF2, ATP1A3, and PDCD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NRBF2 grouped by Endoplasmic reticulum membrane organization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NRBF2 →	+0.570	+1.183	.005	.002	3	4
BLOOD_Leukemia	ATP1A3 →	-2.666	-1.142	.007	.004	2	5
LUNG_SCLC	PDCD5 →	-0.866	-1.466	.009	.002	3	3
BLOOD_Leukemia	RB1 →	-1.576	-1.177	.003	.003	3	3
BLOOD_Lymphoma	CMTM7 →	-4.077	-1.527	.006	<.001	3	3
OESOPHAGUS	ITGA5 →	-1.692	-1.440	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NRBF2 by Endoplasmic reticulum membrane organization activity — CNS

Explore this box plot interactively →