Endoplasmic reticulum membrane organization

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, RPL4, and RPS4X, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum membrane organization activity versus RPL3 in PANCREAS (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPL3 →	-0.678	-0.323	<.001	.002	3	6
STOMACH	RPL4 →	-0.673	-0.275	<.001	.007	3	6
STOMACH	RPS4X →	-0.961	-0.366	.003	<.001	3	6
OVARY	CENPV →	-1.690	-0.251	.001	.002	3	5
BONE	TMOD3 →	+0.869	+0.336	.005	.004	3	5
PANCREAS	RPS11 →	-0.797	-0.367	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090158 vs RPL3 — PANCREAS

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