Positive regulation of sphingolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of sphingolipid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G6, PRKCD, and HSPA1B, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLA2G6 grouped by Positive regulation of sphingolipid biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PLA2G6 →	-0.490	-1.496	.002	.001	3	15
KIDNEY	PRKCD →	-0.459	-2.020	<.001	<.001	3	11
KIDNEY	HSPA1B →	-0.317	-1.346	.004	.006	3	5
SKIN	P3H2 →	-0.125	-1.045	.007	<.001	3	5
LIVER	GPI →	-0.284	-1.654	<.001	.001	3	5
SOFT_TISSUE	EBI3 →	-0.283	-1.283	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLA2G6 by Positive regulation of sphingolipid biosynthetic process activity — LIVER

Explore this box plot interactively →