Positive regulation of sphingolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of sphingolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM2, ATP5MF, and ARL6IP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LSM2 grouped by Positive regulation of sphingolipid biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LSM2 →	+0.370	+0.719	.007	.006	3	4
OESOPHAGUS	ATP5MF →	+0.776	+1.090	.001	.002	3	4
OESOPHAGUS	ARL6IP1 →	+0.748	+1.347	.005	.002	3	4
BLOOD_Lymphoma	ILDR2 →	-0.932	-1.481	.003	<.001	3	3
LARGE_INTESTINE	PLA2G4A →	-1.484	-0.876	.004	<.001	3	3
PANCREAS	SLFN5 →	-1.762	-1.429	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LSM2 by Positive regulation of sphingolipid biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →