Positive regulation of sphingolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of sphingolipid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3A, ANKRD46, and ARHGEF37, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB3A grouped by Positive regulation of sphingolipid biosynthetic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RAB3A →	+0.365	+0.126	<.001	.001	2	6
BLOOD_Leukemia	ANKRD46 →	+0.157	+0.141	<.001	<.001	3	4
SOFT_TISSUE	ARHGEF37 →	-0.218	-0.113	.002	.007	3	4
LARGE_INTESTINE	CROT →	+0.256	+0.193	<.001	.001	3	4
LUNG_SCLC	RALGPS2 →	+0.383	+0.170	<.001	<.001	3	4
LUNG_SCLC	ZNF829 →	+0.285	+0.175	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB3A by Positive regulation of sphingolipid biosynthetic process activity — BLOOD_Lymphoma

Explore this box plot interactively →