Regulation of sphingolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of sphingolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM10, GAS2L3, and ZWILCH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sphingolipid biosynthetic process activity versus MCM10 in BRCA (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MCM10 →	-0.903	-0.675	<.001	<.001	3	4
BRCA	GAS2L3 →	-0.433	-0.457	.001	.001	3	4
BRCA	ZWILCH →	-0.340	-0.568	<.001	<.001	3	4
CCRCC	MIR548I1 →	+0.395	+0.503	.004	.002	3	3
BRCA	USP1 →	-0.508	-0.647	<.001	<.001	3	3
LUAD	FGF14 →	+0.422	+0.579	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090153 vs MCM10 — BRCA

Explore this scatter interactively →