Establishment of protein localization to membrane

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL11, WNK2_S1862, and MAP1A_S1776, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to membrane activity versus RPL11 in GBM (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL11 →	-0.174	-0.030	<.001	<.001	3	5
LUAD	WNK2_S1862 →	+0.858	+0.017	<.001	.002	3	5
BRCA	MAP1A_S1776 →	+0.392	+0.017	.007	.001	3	5
GBM	RTN1 →	+0.518	+0.032	<.001	<.001	3	5
UCEC	JPT1_S131 →	-0.519	-0.052	<.001	.002	3	4
OV	RPS5 →	-0.275	-0.021	.002	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090150 vs RPL11 — GBM

Explore this scatter interactively →