Establishment of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP43, POLR3K, and STIMATE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP43 grouped by Establishment of protein localization to membrane-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	USP43 →	+0.930	+0.248	<.001	.001	3	4
LUNG_NSCLC_LUAD	POLR3K →	+0.591	+0.145	.003	.001	3	4
LUNG_SCLC	STIMATE →	-1.035	-0.166	.006	.002	3	4
BLOOD_Leukemia	KLHDC8B →	-2.309	-0.196	<.001	.001	3	4
PANCREAS	DFFA →	-0.931	-0.144	.003	.004	3	4
PANCREAS	ACAA2 →	-1.153	-0.169	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP43 by Establishment of protein localization to membrane activity — BLOOD_Myeloma

Explore this box plot interactively →