Establishment of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to membrane pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPDL, EDEM2, and ETFDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to membrane activity versus HNRNPDL in LIVER (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HNRNPDL →	-0.764	-0.236	.009	<.001	2	6
SOFT_TISSUE	EDEM2 →	+0.703	+0.161	<.001	.003	3	5
LARGE_INTESTINE	ETFDH →	-0.840	-0.107	<.001	.001	3	5
BLOOD_Myeloma	DDOST →	+0.631	+0.201	.001	<.001	3	5
PANCREAS	CD274 →	+1.497	+0.168	.005	<.001	3	4
PANCREAS	HNRNPA1 →	-0.524	-0.135	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090150 vs HNRNPDL — LIVER

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