Establishment of protein localization to membrane

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDOST, EMC1, and RPN1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to membrane activity versus DDOST in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DDOST →	+0.873	+0.116	<.001	.002	3	18
PANCREAS	EMC1 →	+1.047	+0.222	<.001	<.001	3	18
BONE	RPN1 →	+0.929	+0.199	<.001	<.001	3	18
BLOOD_Myeloma	NCLN →	+0.828	+0.163	.008	.007	2	17
LARGE_INTESTINE	PTMA →	-2.130	-0.200	<.001	<.001	3	16
PANCREAS	SLC25A5 →	+1.094	+0.179	.007	.006	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090150 vs DDOST — BLOOD_Leukemia

Explore this scatter interactively →