Membrane fission

Across TCGA patient cohorts, RNA activity of the Membrane fission pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOS2, CCSER2, and TASOR2, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane fission activity versus SOS2 in UVM (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	SOS2 →	+1.287	+0.071	<.001	<.001	3	34
UVM	CCSER2 →	+1.209	+0.074	<.001	<.001	3	34
UVM	TASOR2 →	+1.664	+0.068	<.001	<.001	3	34
UVM	PRPF4B →	+1.861	+0.075	<.001	<.001	3	34
UVM	SEC24A →	+1.497	+0.072	<.001	<.001	3	34
UVM	PIK3C2A →	+2.301	+0.066	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090148 vs SOS2 — UVM

Explore this scatter interactively →