Membrane fission

Across TCGA patient cohorts, RNA activity of the Membrane fission pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL4, RPL6, and RPS6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane fission activity versus RPL4 in GBM (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL4 →	-0.346	-0.042	<.001	<.001	3	7
GBM	RPL6 →	-0.579	-0.056	<.001	<.001	3	6
GBM	RPS6 →	-0.449	-0.042	<.001	<.001	3	6
BRCA	RPS16 →	-0.172	-0.037	.003	.001	3	6
GBM	SPTAN1 →	+0.463	+0.063	<.001	<.001	3	6
GBM	RPL7 →	-0.378	-0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090148 vs RPL4 — GBM

Explore this scatter interactively →