Membrane fission

Across TCGA patient cohorts, RNA activity of the Membrane fission pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KNTC1, TATDN2, and GNAI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane fission activity versus KNTC1 in PDAC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KNTC1 →	-0.460	-0.171	.002	<.001	3	5
LUAD	TATDN2 →	-0.249	-0.116	.006	.005	3	5
UCEC	GNAI2 →	-0.334	-0.124	.002	.007	3	4
UCEC	TTF2 →	-0.526	-0.181	.004	<.001	3	4
UCEC	GBP1 →	-1.221	-0.181	.001	.005	3	4
UCEC	METTL3 →	-0.663	-0.195	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090148 vs KNTC1 — PDAC

Explore this scatter interactively →