Membrane fission

Across TCGA cell cohorts, RNA activity of the Membrane fission pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM124A, KCNK1, and ARHGDIB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM124A grouped by Membrane fission-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FAM124A →	-0.648	-0.266	.004	.001	3	6
STOMACH	KCNK1 →	+2.645	+0.232	.003	.005	3	5
URINARY_TRACT	ARHGDIB →	+5.327	+0.374	.009	.003	3	5
PANCREAS	TSPAN1 →	+3.043	+0.229	<.001	.003	3	5
LUNG_NSCLC_LUAD	REEP5 →	+0.538	+0.171	.002	.008	2	6
PANCREAS	LANCL1 →	-0.702	-0.181	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM124A by Membrane fission activity — OVARY

Explore this box plot interactively →