Membrane fission

Across TCGA cell cohorts, RNA activity of the Membrane fission pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL21A, CORO1C, and CLEC16A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane fission activity versus METTL21A in PANCREAS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	METTL21A →	+0.890	+1.279	.001	<.001	3	6
OVARY	CORO1C →	+0.979	+1.108	.004	.002	3	6
CNS	CLEC16A →	+0.541	+1.105	<.001	.001	3	5
PANCREAS	ACO1 →	+1.420	+1.260	<.001	.004	3	5
URINARY_TRACT	QTRT2 →	+0.466	+1.350	.005	<.001	3	5
SKIN	CHKA →	+1.193	+1.096	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090148 vs METTL21A — PANCREAS

Explore this scatter interactively →