Positive regulation of mitochondrial fission

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial fission pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FHL3, FN1, and RPL4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial fission activity versus FHL3 in COAD (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FHL3 →	+0.603	+0.042	<.001	<.001	3	6
BRCA	FN1 →	+0.587	+0.021	<.001	.008	3	6
COAD	RPL4 →	-0.294	-0.030	<.001	<.001	3	6
COAD	RPL5 →	-0.202	-0.034	<.001	<.001	3	6
COAD	DPYSL3 →	+0.789	+0.041	<.001	<.001	3	6
CCRCC	ISLR →	+0.526	+0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090141 vs FHL3 — COAD

Explore this scatter interactively →