Regulation of mitochondrial fission

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial fission pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP34, DYNC1LI2, and TASOR2, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial fission activity versus USP34 in UCS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	USP34 →	+1.638	+0.052	<.001	<.001	3	32
THYM	DYNC1LI2 →	+1.377	+0.032	<.001	<.001	3	32
UVM	TASOR2 →	+1.159	+0.036	.001	<.001	3	31
DLBC	PIKFYVE →	+1.073	+0.053	<.001	<.001	3	31
ACC	PCNX4 →	+0.922	+0.042	<.001	<.001	3	31
UVM	VPS13B →	+1.050	+0.025	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090140 vs USP34 — UCS

Explore this scatter interactively →