Regulation of mitochondrial fission

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial fission pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL_S795, RPL10A, and RPL11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial fission activity versus VCL_S795 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VCL_S795 →	+0.443	+0.023	.001	.003	3	7
CCRCC	RPL10A →	-0.239	-0.032	<.001	.001	3	6
COAD	RPL11 →	-0.173	-0.027	<.001	<.001	3	6
COAD	RPL6 →	-0.182	-0.023	.001	<.001	3	6
CCRCC	RPL7 →	-0.167	-0.027	.008	.003	3	6
COAD	RPS5 →	-0.231	-0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090140 vs VCL_S795 — BRCA

Explore this scatter interactively →