Regulation of mitochondrial fission

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial fission pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BATF3, RAI14, and SRPX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial fission activity versus BATF3 in COAD (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BATF3 →	-0.524	-0.180	<.001	<.001	3	6
BRCA	RAI14 →	-0.503	-0.223	.008	.006	3	5
PDAC	SRPX →	-0.557	-0.164	.002	.003	3	5
GBM	DCN →	-0.994	-0.106	.002	.008	3	4
GBM	CTHRC1 →	-0.843	-0.096	.008	.008	3	4
LUAD	SEC23A →	-0.374	-0.124	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090140 vs BATF3 — COAD

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