Regulation of mitochondrial fission

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial fission pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFIA, APLP1, and MCU, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial fission activity versus NFIA in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NFIA →	+1.443	+0.194	.004	.002	3	5
LUNG_NSCLC_LUAD	APLP1 →	-2.065	-0.320	.003	<.001	3	4
OVARY	MCU →	+1.259	+0.328	<.001	<.001	3	4
STOMACH	MRPL44 →	+0.607	+0.265	.009	.006	3	4
PANCREAS	AP1S3 →	+1.276	+0.254	.004	.001	3	4
PANCREAS	FAM81A →	+1.188	+0.294	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090140 vs NFIA — BLOOD_Lymphoma

Explore this scatter interactively →