Epithelial cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Epithelial cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP4R3A, WDR33, and LY9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell-cell adhesion activity versus PPP4R3A in UCEC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP4R3A →	+0.337	+0.362	<.001	.004	3	5
CCRCC	WDR33 →	+0.224	+0.626	<.001	.001	3	5
LUAD	LY9 →	-0.478	-0.481	.001	.001	3	5
HNSC	RAB25 →	+0.829	+1.142	.003	<.001	3	5
HNSC	ZBTB7B →	+0.500	+0.951	<.001	<.001	3	5
HNSC	MAP3K9 →	+0.566	+1.110	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090136 vs PPP4R3A — UCEC

Explore this scatter interactively →