Epithelial cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Epithelial cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNMB3, TMEM45B, and C17orf67, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNMB3 grouped by Epithelial cell-cell adhesion-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KCNMB3 →	-1.366	-2.169	.005	<.001	3	6
LUNG_NSCLC_LUSC	TMEM45B →	-3.476	-1.412	.001	<.001	3	5
LUNG_NSCLC_LUSC	C17orf67 →	+0.941	+1.807	<.001	<.001	3	5
LUNG_NSCLC_LUSC	PRXL2C →	+1.306	+1.838	.007	<.001	3	4
STOMACH	JAK3 →	+0.792	+0.947	.006	.006	3	4
SOFT_TISSUE	JAZF1 →	+1.781	+1.053	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNMB3 by Epithelial cell-cell adhesion activity — URINARY_TRACT

Explore this box plot interactively →