Epithelial cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Epithelial cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM104, TCN2, and KIFC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell-cell adhesion activity versus TMEM104 in LUNG_SCLC (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM104 →	-0.734	-0.330	.006	.006	3	5
BLOOD_Lymphoma	TCN2 →	-1.488	-0.242	.002	.004	3	5
LUNG_SCLC	KIFC3 →	-2.001	-0.339	.002	.002	3	5
URINARY_TRACT	NUP188 →	-0.905	-0.354	<.001	.008	3	5
URINARY_TRACT	DHPS →	-1.070	-0.397	<.001	.009	3	5
LUNG_NSCLC_LUAD	SYTL1 →	+1.991	+0.196	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090136 vs TMEM104 — LUNG_SCLC

Explore this scatter interactively →