Mesenchyme migration

Across TCGA patient cohorts, RNA activity of the Mesenchyme migration pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, ACTG2, and MYL9, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchyme migration activity versus ACTA2 in SARC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	ACTA2 →	+3.001	+0.191	<.001	<.001	3	30
SARC	ACTG2 →	+5.152	+0.212	<.001	<.001	3	26
SARC	MYL9 →	+2.515	+0.164	<.001	<.001	3	25
SARC	CNN1 →	+4.395	+0.183	<.001	<.001	3	25
SARC	TPM2 →	+2.845	+0.169	<.001	<.001	3	25
SARC	MYH11 →	+4.797	+0.157	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090131 vs ACTA2 — SARC

Explore this scatter interactively →