Mesenchyme migration

Across TCGA patient cohorts, RNA activity of the Mesenchyme migration pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYLK, TAGLN, and MYL9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchyme migration activity versus MYLK in UCEC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYLK →	+0.954	+0.160	<.001	<.001	3	8
GBM	TAGLN →	+1.237	+0.205	<.001	.008	3	7
BRCA	MYL9 →	+1.014	+0.605	<.001	<.001	3	7
UCEC	CNN1 →	+2.016	+0.145	<.001	<.001	3	7
LUAD	MYH11 →	+1.264	+0.260	<.001	.004	3	7
UCEC	LMOD1 →	+1.136	+0.127	.004	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090131 vs MYLK — UCEC

Explore this scatter interactively →