Mesenchyme migration

Across TCGA cell cohorts, RNA activity of the Mesenchyme migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F10, MED26, and GDPD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, F10 grouped by Mesenchyme migration-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	F10 →	-0.440	-0.124	<.001	<.001	3	4
OESOPHAGUS	MED26 →	-0.504	-0.102	.001	.006	3	4
OESOPHAGUS	GDPD1 →	-1.195	-0.114	.005	.005	3	4
OESOPHAGUS	GARRE1 →	-1.858	-0.152	.004	.001	3	3
LARGE_INTESTINE	GPI →	-0.528	-0.204	.003	.001	3	3
OESOPHAGUS	UBE2Z →	-0.713	-0.098	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

F10 by Mesenchyme migration activity — OESOPHAGUS

Explore this box plot interactively →