Mesenchyme migration

Across TCGA cell cohorts, RNA activity of the Mesenchyme migration pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, UBR2, and SLC3A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Mesenchyme migration-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MDM2 →	+0.573	+1.048	.002	.004	3	5
BLOOD_Leukemia	UBR2 →	-0.218	-1.010	<.001	<.001	3	5
CNS	SLC3A2 →	-0.147	-1.244	.008	.001	3	5
CNS	FH →	-0.173	-1.335	.009	<.001	3	4
BONE	KIF2C →	+0.228	+1.704	<.001	.003	2	5
BLOOD_Lymphoma	LCN12 →	-0.353	-2.173	.002	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Mesenchyme migration activity — SKIN

Explore this box plot interactively →