Positive regulation of synapse maturation

Across TCGA patient cohorts, RNA activity of the Positive regulation of synapse maturation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPDC1B, PDCL, and CENPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synapse maturation activity versus DEPDC1B in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DEPDC1B →	+0.979	+0.759	<.001	<.001	3	6
HNSC	PDCL →	+0.397	+0.404	.004	.002	3	5
BRCA	CENPA →	+1.034	+0.687	<.001	.001	3	5
BRCA	OIP5 →	+0.575	+0.584	<.001	<.001	3	5
GBM	GPSM2 →	+0.547	+0.526	<.001	<.001	3	5
BRCA	CKS2 →	+0.840	+0.953	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090129 vs DEPDC1B — GBM

Explore this scatter interactively →