Positive regulation of synapse maturation

Across TCGA cell cohorts, RNA activity of the Positive regulation of synapse maturation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SBF1, CHGA, and GMEB2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SBF1 grouped by Positive regulation of synapse maturation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SBF1 →	-0.195	-0.237	.008	.009	1	1
LARGE_INTESTINE	CHGA →	-0.240	-0.237	.004	.009	1	1
LARGE_INTESTINE	GMEB2 →	+0.240	+0.237	.003	.009	1	1
LARGE_INTESTINE	STS →	+0.150	+0.237	.004	.009	1	1
LARGE_INTESTINE	INTS6 →	-0.154	-0.237	.005	.009	1	1
LARGE_INTESTINE	CACNG7 →	+0.290	+0.237	.005	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SBF1 by Positive regulation of synapse maturation activity — LARGE_INTESTINE

Explore this box plot interactively →