Positive regulation of synapse maturation

Across TCGA cell cohorts, RNA activity of the Positive regulation of synapse maturation pathway is significantly associated with the total protein of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are VHL, Tuberin_pT1462, and p90 RSK, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synapse maturation activity versus VHL in BLOOD_Lymphoma (Pearson r = -0.97).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	VHL →	-2.050	-0.460	.003	.034	1	3
LARGE_INTESTINE	Tuberin_pT1462 →	-0.598	-0.237	.044	.009	1	2
BLOOD_Lymphoma	p90 RSK →	+0.262	+0.460	.041	.034	1	2
BLOOD_Lymphoma	RSK1-2-3 →	+0.465	+0.460	.035	.034	1	2
BLOOD_Lymphoma	Caspase-7-cleavedD198 →	-0.577	-0.460	.028	.034	1	2
LARGE_INTESTINE	ERK2 →	+0.385	+0.237	.030	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090129 vs VHL — BLOOD_Lymphoma

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