Vesicle-mediated cholesterol transport

Across TCGA patient cohorts, RNA activity of the Vesicle-mediated cholesterol transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF212, RNA5SP512, and PRKAG2-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle-mediated cholesterol transport activity versus ZNF212 in OV (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF212 →	+0.453	+0.106	<.001	<.001	3	3
OV	RNA5SP512 →	+0.407	+0.088	.004	.005	3	3
OV	PRKAG2-AS1 →	+0.996	+0.142	<.001	<.001	3	3
GBM	SLIT3-AS1 →	+0.460	+0.142	.001	.004	3	3
OV	FAM234B →	+0.496	+0.097	.003	.001	3	3
LUAD	TXNL4AP1 →	+0.431	+0.096	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090119 vs ZNF212 — OV

Explore this scatter interactively →