Vesicle-mediated cholesterol transport

Across TCGA cell cohorts, RNA activity of the Vesicle-mediated cholesterol transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP11, ZNF485, and ARL8B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle-mediated cholesterol transport activity versus MMP11 in BLOOD_Lymphoma (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MMP11 →	-1.871	-1.144	.002	.001	3	5
OESOPHAGUS	ZNF485 →	-0.931	-1.206	<.001	<.001	3	5
BLOOD_Leukemia	ARL8B →	+0.711	+0.907	<.001	<.001	3	5
OVARY	DHX33 →	-1.162	-1.309	.003	<.001	2	6
PANCREAS	C3 →	+4.334	+1.510	.002	.002	3	5
BLOOD_Leukemia	RXRA →	+1.510	+0.935	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090119 vs MMP11 — BLOOD_Lymphoma

Explore this scatter interactively →