Cochlea morphogenesis

Across TCGA patient cohorts, RNA activity of the Cochlea morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC24A, GBP1, and GBP5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cochlea morphogenesis activity versus SEC24A in CCRCC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEC24A →	-0.287	-0.059	<.001	<.001	3	7
LSCC	GBP1 →	-0.567	-0.049	.001	.009	3	7
CCRCC	GBP5 →	-0.650	-0.046	<.001	<.001	3	7
CCRCC	PPP6R1 →	-0.131	-0.039	<.001	.002	3	7
CCRCC	PSME2 →	-0.340	-0.065	<.001	<.001	3	7
COAD	PTPN7 →	-0.503	-0.057	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090103 vs SEC24A — CCRCC

Explore this scatter interactively →