Cochlea morphogenesis

Across TCGA patient cohorts, RNA activity of the Cochlea morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX2, LHFPL6, and INKA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cochlea morphogenesis activity versus TBX2 in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TBX2 →	+1.279	+0.348	<.001	.009	3	8
BRCA	LHFPL6 →	+0.821	+0.555	.004	.002	3	7
LUAD	INKA2 →	+0.476	+0.825	<.001	<.001	3	7
GBM	TBX2-AS1 →	+0.785	+0.562	<.001	<.001	3	7
OV	NR2F2 →	+0.658	+0.292	<.001	.005	3	6
UCEC	RHOJ →	+1.195	+0.538	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090103 vs TBX2 — OV

Explore this scatter interactively →