Cochlea morphogenesis

Across TCGA cell cohorts, RNA activity of the Cochlea morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB21, POLR1D, and GRB14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB21 grouped by Cochlea morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RAB21 →	+0.927	+1.414	.005	.005	3	5
STOMACH	POLR1D →	+0.867	+0.778	.003	.006	3	5
BREAST	GRB14 →	+1.373	+0.749	.003	.004	3	4
LUNG_NSCLC_LUSC	CALB2 →	-2.861	-1.125	.002	<.001	3	4
BONE	COMMD1 →	+0.687	+1.463	.007	.002	3	4
BLOOD_Myeloma	BAX →	+1.083	+1.142	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB21 by Cochlea morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →