Cochlea morphogenesis

Across TCGA cell cohorts, RNA activity of the Cochlea morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR2C3, TLR7, and SLC39A10, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR2C3 grouped by Cochlea morphogenesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2C3 →	+0.275	+0.820	.008	.006	1	1
LUNG_NSCLC_LUAD	TLR7 →	-0.130	-0.820	.005	.006	1	1
LUNG_NSCLC_LUAD	SLC39A10 →	-0.175	-0.820	.007	.006	1	1
LUNG_NSCLC_LUAD	ZNF461 →	-0.360	-0.820	.003	.006	1	1
LUNG_NSCLC_LUAD	LRRC10 →	+0.194	+0.820	.008	.006	1	1
LUNG_NSCLC_LUAD	ZNF788P →	+0.300	+0.820	.005	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR2C3 by Cochlea morphogenesis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →