Cochlea development

Across TCGA patient cohorts, RNA activity of the Cochlea development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNPY4, FKBP9, and PSME2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cochlea development activity versus CNPY4 in UCEC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNPY4 →	+0.494	+0.091	<.001	<.001	3	8
LSCC	FKBP9 →	+0.426	+0.054	<.001	<.001	3	7
LSCC	PSME2 →	-0.386	-0.053	<.001	<.001	3	7
LSCC	STAT1 →	-0.498	-0.047	.003	<.001	2	8
CCRCC	NID1 →	+0.422	+0.051	.001	<.001	3	7
CCRCC	ARHGEF17 →	+0.366	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090102 vs CNPY4 — UCEC

Explore this scatter interactively →