Cochlea development

Across TCGA cell cohorts, RNA activity of the Cochlea development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCP1, C2orf15, and CYB5R3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cochlea development activity versus TCP1 in OESOPHAGUS (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TCP1 →	-0.698	-0.336	<.001	<.001	3	5
STOMACH	C2orf15 →	+1.737	+0.337	.002	.001	3	5
SOFT_TISSUE	CYB5R3 →	-0.925	-0.447	<.001	.003	3	4
LUNG_NSCLC_LUSC	SMARCAL1 →	-0.884	-0.359	.009	.005	3	4
OESOPHAGUS	NFU1 →	-0.833	-0.237	<.001	.002	3	4
OESOPHAGUS	STAM →	-0.789	-0.265	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090102 vs TCP1 — OESOPHAGUS

Explore this scatter interactively →