Positive regulation of extracellular matrix disassembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of extracellular matrix disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are P3H3, CRTAP, and FAP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extracellular matrix disassembly activity versus P3H3 in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	P3H3 →	+0.560	+0.067	.005	<.001	3	9
LUAD	CRTAP →	+0.496	+0.117	<.001	<.001	3	8
COAD	FAP →	+0.668	+0.059	<.001	<.001	3	8
BRCA	P3H1 →	+0.435	+0.036	<.001	<.001	3	8
CCRCC	TIMP2 →	+0.513	+0.104	<.001	<.001	3	8
LUAD	COL5A2 →	+0.651	+0.105	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090091 vs P3H3 — OV

Explore this scatter interactively →