Positive regulation of extracellular matrix disassembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of extracellular matrix disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AW, MYH9, and KHNYN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extracellular matrix disassembly activity versus H2AW in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	H2AW →	+1.139	+0.781	.002	.001	3	4
GBM	MYH9 →	-0.611	-0.640	.001	.002	3	3
GBM	KHNYN →	-0.444	-0.708	<.001	<.001	3	3
GBM	SYNGR3 →	+1.003	+0.596	.005	.004	3	3
GBM	WDPCP →	+0.318	+0.592	<.001	<.001	3	3
GBM	LINC00242 →	+0.224	+0.540	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090091 vs H2AW — BRCA

Explore this scatter interactively →