Positive regulation of extracellular matrix disassembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of extracellular matrix disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H12B, ARMC2, and MYL12B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZC3H12B grouped by Positive regulation of extracellular matrix disassembly-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZC3H12B →	+0.887	+0.677	<.001	.007	3	3
BONE	ARMC2 →	+1.279	+0.568	.003	.003	3	3
UPPER_AERODIGESTIVE_TRACT	MYL12B →	-1.282	-0.473	.009	.003	3	3
UPPER_AERODIGESTIVE_TRACT	EPHA10 →	-0.698	-0.549	.001	<.001	3	3
LARGE_INTESTINE	AIMP1 →	+0.578	+0.602	.006	.005	3	3
CNS	PPID →	+0.391	+0.672	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZC3H12B by Positive regulation of extracellular matrix disassembly activity — BONE

Explore this box plot interactively →