Positive regulation of extracellular matrix disassembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of extracellular matrix disassembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, TLN1, and WRN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Positive regulation of extracellular matrix disassembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TEAD1 →	+0.787	+0.276	<.001	<.001	3	5
LIVER	TLN1 →	+0.683	+0.300	.005	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	WRN →	+0.293	+0.184	.007	.003	3	4
SKIN	DSE →	-0.241	-0.179	.001	<.001	3	4
OVARY	NMNAT1 →	+0.210	+0.199	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SLC25A37 →	-0.105	-0.274	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Positive regulation of extracellular matrix disassembly activity — LIVER

Explore this box plot interactively →