Negative regulation of canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOL3, STX2, and ESAM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APOL3 grouped by Negative regulation of canonical Wnt signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	APOL3 →	-1.282	-0.139	.004	.005	3	4
KIDNEY	STX2 →	-0.717	-0.214	.002	.001	3	4
KIDNEY	ESAM →	-1.013	-0.191	.007	.001	3	4
OESOPHAGUS	ZC2HC1A →	-1.327	-0.134	.001	.001	2	5
BREAST	BRIP1 →	+0.975	+0.108	.001	.008	3	3
STOMACH	EMC9 →	+0.776	+0.143	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APOL3 by Negative regulation of canonical Wnt signaling pathway activity — STOMACH

Explore this box plot interactively →