Negative regulation of canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of canonical Wnt signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDHC, BCL2L13, and PLEKHG5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDHC grouped by Negative regulation of canonical Wnt signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SDHC →	-0.242	-0.049	.002	.006	3	5
BLOOD_Myeloma	BCL2L13 →	+0.156	+0.045	.001	<.001	2	6
LUNG_SCLC	PLEKHG5 →	-0.160	-0.033	.005	.008	3	4
KIDNEY	TAL2 →	-0.200	-0.041	.003	.004	3	4
OESOPHAGUS	ETV2 →	-0.145	-0.056	<.001	<.001	3	4
LARGE_INTESTINE	DUSP3 →	+0.120	+0.042	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDHC by Negative regulation of canonical Wnt signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →