Negative regulation of canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUSD6, CTNND1, and TRIOBP, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of canonical Wnt signaling pathway activity versus SUSD6 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SUSD6 →	+0.821	+0.043	.002	.001	3	10
URINARY_TRACT	CTNND1 →	+0.959	+0.049	.006	.002	2	11
LUNG_NSCLC_LUAD	TRIOBP →	+0.911	+0.040	<.001	<.001	3	10
PANCREAS	COA6 →	-0.666	-0.055	.002	.001	2	11
BONE	AJUBA →	+1.676	+0.033	<.001	.002	3	9
PANCREAS	LRRC8A →	+1.723	+0.070	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090090 vs SUSD6 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →