Regulation of peptide transport

Across TCGA patient cohorts, RNA activity of the Regulation of peptide transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX42, RFC1, and COIL_T303, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptide transport activity versus DDX42 in PDAC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DDX42 →	-0.171	-0.031	.006	.004	3	6
UCEC	RFC1 →	-0.233	-0.028	.004	.003	3	5
OV	COIL_T303 →	-0.980	-0.023	.001	.006	3	5
BRCA	RPN1 →	-0.284	-0.020	.005	<.001	3	5
PDAC	ZBTB21_S345 →	-0.347	-0.030	<.001	<.001	3	5
BRCA	DNAJC12 →	+0.625	+0.011	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090087 vs DDX42 — PDAC

Explore this scatter interactively →