Regulation of protein deubiquitination

Across TCGA patient cohorts, RNA activity of the Regulation of protein deubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARD16, DPYD, and LGALS9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein deubiquitination activity versus CARD16 in GBM (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CARD16 →	+0.710	+0.054	<.001	<.001	3	7
LSCC	DPYD →	+0.426	+0.073	<.001	<.001	3	7
BRCA	LGALS9 →	+0.507	+0.068	<.001	<.001	3	7
GBM	GBP4 →	+0.514	+0.057	<.001	<.001	3	7
GBM	LCP2 →	+0.513	+0.074	<.001	<.001	3	7
LSCC	GMFG →	+0.526	+0.068	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090085 vs CARD16 — GBM

Explore this scatter interactively →