Regulation of protein deubiquitination

Across TCGA patient cohorts, RNA activity of the Regulation of protein deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASL11A, WNT2B, and CDK2AP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein deubiquitination activity versus RASL11A in LSCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RASL11A →	-1.054	-0.819	<.001	<.001	3	4
LSCC	WNT2B →	-0.844	-0.602	.004	.003	3	4
LSCC	CDK2AP2 →	+0.410	+0.783	.001	<.001	3	4
OV	REEP1 →	-0.759	-0.467	<.001	.004	3	4
LSCC	PPP1R3E →	-0.252	-0.411	.009	.005	3	4
HNSC	TNS2 →	-0.417	-0.275	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090085 vs RASL11A — LSCC

Explore this scatter interactively →