Regulation of protein deubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTTG1, CORO1A, and NARF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTTG1 grouped by Regulation of protein deubiquitination-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PTTG1 →	-1.025	-0.236	.001	.003	3	4
OESOPHAGUS	CORO1A →	+1.282	+0.140	.001	.007	3	3
OESOPHAGUS	NARF →	+0.953	+0.209	<.001	.001	3	3
OESOPHAGUS	RNF168 →	-0.506	-0.151	.005	.006	3	3
OESOPHAGUS	RAB40A →	+0.615	+0.159	.007	.001	2	4
OESOPHAGUS	CYBC1 →	+0.956	+0.166	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTTG1 by Regulation of protein deubiquitination activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →