Regulation of protein deubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PVR, TOP1MT, and NPTN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein deubiquitination activity versus PVR in LUNG_NSCLC_LUSC (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PVR →	-1.385	-0.224	.001	.002	3	7
URINARY_TRACT	TOP1MT →	+1.317	+0.454	.006	.008	3	7
LUNG_SCLC	NPTN →	-0.717	-0.175	.002	<.001	3	7
BLOOD_Leukemia	NEK6 →	-2.220	-0.118	.004	.001	3	7
LIVER	TGM2 →	-3.897	-0.332	.002	.003	3	6
CNS	CD63 →	-1.414	-0.230	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090085 vs PVR — LUNG_NSCLC_LUSC

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